Establishment of a xenograft model of human myelodysplastic syndromes

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Establishment of a xenograft model of human myelodysplastic syndromes.

BACKGROUND To understand how myelodysplastic syndrome cells evolve from normal stem cells and gain competitive advantages over normal hematopoiesis, we established a murine xenograft model harboring bone marrow cells from patients with myelodysplastic syndromes or acute myeloid leukemia with myelodysplasia-related changes. DESIGN AND METHODS Bone marrow CD34(+) cells obtained from patients we...

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ژورنال

عنوان ژورنال: Haematologica

سال: 2010

ISSN: 0390-6078,1592-8721

DOI: 10.3324/haematol.2010.027557